CD47 / IAP (Integrin Associated Protein) Antibody - Without BSA and Azide
Mouse Monoclonal Antibody [Clone B6H12.2 ]
|Application ||IHC-P, IF, FC|
|Other Accession||961, 446414|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Leukocyte surface antigen CD47, Antigenic surface determinant protein OA3, Integrin-associated protein, IAP, Protein MER6, CD47, CD47, MER6|
|Format||200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD47 / IAP (Integrin Associated Protein) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain|
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Provided below are standard protocols that you may find useful for product applications.
This antibody reacts with Ig domain of CD47 protein. It has been shown to inhibit polymorphonuclear neutrophil (PMN) transmigration across cell monolayers and matrix. CD47, originally named integrin-associated protein (IAP), is a 50kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus.Ā CD47 may play a role in membrane transport and/or integrin dependent signal transduction.Ā
Edris B et. al. Proc Natl Acad Sci USA 109:6656-61 (2012). | Willingham SB et. al. Proc Natl Acad Sci USA 109:6662-7 (2012)
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