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>   home   >   Products   >   Primary Antibodies   >   Immunology   >    CD63 (Late Endosomes Marker) Antibody - Without BSA and Azide   

CD63 (Late Endosomes Marker) Antibody - Without BSA and Azide

Mouse Monoclonal Antibody [Clone MX-49.129.5 ]

  • IHC -  CD63 (Late Endosomes Marker) Antibody - Without BSA and Azide AH10885
    Formalin-fixed, paraffin-embedded human Melanoma stained with CD63 Monoclonal Antibody (MX-49.129.5)
  • IHC -  CD63 (Late Endosomes Marker) Antibody - Without BSA and Azide AH10885
    Formalin-fixed, paraffin-embedded mouse spleen stained with CD63 Monoclonal Antibody (MX-49.129.5)
  • WB -  CD63 (Late Endosomes Marker) Antibody - Without BSA and Azide AH10885
    Western Blot of human Spleen Lysate with CD63 Monoclonal Antibody (MX-49.129.5)
  • FC -  CD63 (Late Endosomes Marker) Antibody - Without BSA and Azide AH10885
    Flow Cytometry of NIH/3T3 Cells.Black: Cells alone; Green: Isotype Control; Red: PE-labeled CD63 Monoclonal Antibody (MX-49.129.5).
  • IF -  CD63 (Late Endosomes Marker) Antibody - Without BSA and Azide AH10885
    IF staining of HeLa cells using AF488 labeled CD63 Monoclonal Antibody (MX-49.129.5) (green). F-actin filaments are labeled with Dylight 554 phalloidin (red). Nuclei stained with DAPI (blue).
  • IHC -  CD63 (Late Endosomes Marker) Antibody - Without BSA and Azide AH10885
    Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with CD63 Monoclonal Antibody (MX-49.129.5)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08962
Other Accession 967, 445570
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names MX-49.129.5
Calculated MW 26kDa (core protein); 30-60kDa (glycosylated)
Additional Information
Gene ID 967
Other Names CD63 antigen, Granulophysin, Lysosomal-associated membrane protein 3, LAMP-3, Melanoma-associated antigen ME491, OMA81H, Ocular melanoma-associated antigen, Tetraspanin-30, Tspan-30, CD63, CD63, MLA1, TSPAN30
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD63 (Late Endosomes Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD63
Synonyms MLA1, TSPAN30
Function Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Cellular Location Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies
Tissue Location Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages
Research Areas
Citations (0)

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This MAb recognizes protein of 26kDa-60kDa, which is identified as CD63. Its epitope is different from that of MAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.


C. Vennegoor et al., Int. J. Cancer 35: 287-295, 1985. | AA Palmer et al., Pathology 17: 335-339, 1985. | EC Hagen et al., Histopathology 10: 689-700, 1986. |

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$ 354.00
$ 484.00
Cat# AH10885
(40 western blots)
Availability: 2-3 days
Bulk Size
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