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CD8A (Anti-Mouse) (Cytotoxic / Suppressor T-Cell Marker) Antibody - With BSA and Azide

Rat Monoclonal Antibody [Clone IBL-3/25 ]

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01731
Other Accession 12525 (Mouse), 1858 (Mouse)
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype Rat / IgG1, kappa
Clone Names IBL-3/25
Calculated MW 32kDa
Additional Information
Gene ID 12525
Other Names T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein Lyt-2, CD8a, Cd8a, Lyt-2, Lyt2
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD8A (Anti-Mouse) (Cytotoxic / Suppressor T-Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Cd8a
Synonyms Lyt-2, Lyt2
Function Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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Recognizes a protein of 32kDa, identified as CD8a (also known as CD8 chain, T cell co-receptor). CD8 molecule consists of two chains, termed and chain, which are expressed as a disulphide-linked heterodimer or as an homodimer. CD8 is expressed on T cell subset (cytotoxic/suppressor T cells), thymocytes and NK cells. The majority of CD8+ T-cells expresses CD8 as heterodimer. Some subpopulation of CD8+ T cells as well as NK cells may express homodimer. CD8 functions as a co-receptor in concert with TCR for binding the MHC class I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 chain (but not chain). The cytoplasmic domain of CD8 associates with p56lck tyrosine kinase.


Knapp W. et. al. Leukocyte Typing IV, p342-343, Oxford University Press, 1989 Parnes JR, CD4 and CD8 in T cell lineage commitment: alterations induced by expression of a CD8/CD4 chimeric transgene. Semin Immunol 1994, 6:221-229. Leahy DJ. A structural view of CD4 and CD8. FASEB J. 1995,9(1):17-25

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$ 124.00
$ 324.00
$ 454.00
Cat# AH10904
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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