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>   home   >   Products   >   Primary Antibodies   >    Human Immunodeficiency Virus Type-1 p24 (HIV1-p24) Antibody - Without BSA   

Human Immunodeficiency Virus Type-1 p24 (HIV1-p24) Antibody - Without BSA

Mouse Monoclonal Antibody [Clone HIV1-24/661 ]

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04585
Other Accession 155348 (HIV-1)
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names HIV1-24/661
Calculated MW 24kDa (mature); 55kDa & 41kDa (precursors)
Additional Information
Gene ID 155348
Other Names Gag-Pol polyprotein, Pr160Gag-Pol, Matrix protein p17, MA, Capsid protein p24, CA, Spacer peptide p1, Nucleocapsid protein p7, NC, Transframe peptide, TF, p6-pol, p6*, Protease,, PR, Retropepsin, Reverse transcriptase/ribonuclease H,,,, Exoribonuclease H,, p66 RT, p51 RT, p15, Integrase, IN, gag-pol
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Human Immunodeficiency Virus Type-1 p24 (HIV1-p24) Antibody - Without BSA is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name gag-pol
Function Gag-Pol polyprotein: Mediates, with Gag polyrotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi). Gag-Pol polyprotein may regulate its own translation, by the binding genomic RNA in the 5'-UTR. At low concentration, the polyprotein would promote translation, whereas at high concentration, the polyprotein would encapsidate genomic RNA and then shutt off translation. Capsid protein p24: Forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion (PubMed:8648689). Most core are conical, with only 7% tubular. The core is constituted by capsid protein hexamer subunits. The core is disassembled soon after virion entry (PubMed:12660176). Host restriction factors such as monkey TRIM5-alpha or TRIMCyp bind retroviral capsids and cause premature capsid disassembly, leading to blocks in reverse transcription. Capsid restriction by TRIM5 is one of the factors which restricts HIV-1 to the human species (PubMed:23785198). Host PIN1 apparently facilitates the virion uncoating (By similarity). On the other hand, interactions with PDZD8 or CYPA stabilize the capsid (PubMed:24554657).
Cellular Location Gag-Pol polyprotein: Host cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:P12493}. Host endosome, host multivesicular body {ECO:0000250|UniProtKB:P12493}. Note=These locations are linked to virus assembly sites. The main location is the cell membrane, but under some circumstances, late endosomal compartments can serve as productive sites for virion assembly {ECO:0000250|UniProtKB:P12493} Capsid protein p24: Virion. Reverse transcriptase/ribonuclease H: Virion
Citations (0)

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Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.


Voltersvik, P., Bostad, L., Dyrhol-Riise, A.M., Eide, G.E., Rosok, B.I., Olofsson, J. and Asjo, B. 2006. Cystatin A and HIV-1 p24 antigen expression in tonsil- lar lymphoid follicles during HIV-1 infection and during highly active anti- retroviral therapy. J. Acquir. Immune Defic. Syndr. 41: 277-2784

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