Melanoma Marker (MART-1 + gp100 + Tyrosinase) Antibody - Without BSA and Azide
Mouse Monoclonal Antibody [Clone M2-7C10 + M2-9E3 + HMB45 + T311 ]
|Other Accession||2315-MART-1, 7299-Tyrosinase, 6490-gp100, 154069-MART-1, 503555-Tyrosinase, 95972-gp100, P14679, P40967|
|Isotype||Mouse / IgG1, IgG2a & IgG2b, kappa|
|Clone Names||M2-7C10 + M2-9E3 + HMB45 + T311|
|Calculated MW||20-22kDa (doublet) (MART); 70-80kDa (Tyrosinase); 90-100kDa (gp100)|
|Format||200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Melanoma Marker (MART-1 + gp100 + Tyrosinase) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody cocktail recognizes three melanoma-specific proteins, which include MART-1, Tyrosinase and gp100. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Function of gp100 is not known but it is reported to be a useful marker for melanocytes and melanomas. This cocktail of three markers is designed for extremely sensitive labeling of formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.
Chen Y-T, et. al. Proc Natl Acad Sci, USA, 1996, 93:5915-19.Chen Y-T, et. al. Proc. Natl. Acad. Sci. USA, 1995, 92:8125-8129.Gown AM, et. al. American Journal of Pathology, 1986, 123(2):195-203
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