Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody
Mouse Monoclonal Antibody [Clone CDH16/1071 ]
|Application ||IHC, IF, FC|
|Other Accession||1014, 513660|
|Reactivity||Human, Mouse, Rat, Rabbit, Dog|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Cadherin-16, Kidney-specific cadherin, Ksp-cadherin, CDH16|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Kidney specific.|
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This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.ĀKsp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.
Shen, S.S., et al. 2005. Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms. Mod Pathol. 18: 933-40. | Mazal, P.R., et al. 2005. Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol. 36: 22-28. |
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