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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >    p27Kip1 (Mitotic Inhibitor/Suppressor Protein) Antibody   

p27Kip1 (Mitotic Inhibitor/Suppressor Protein) Antibody

Mouse Monoclonal Antibody [Clone SPM348 ]

  • IHC -  p27Kip1 (Mitotic Inhibitor/Suppressor Protein) Antibody AH11005
    Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with p27 Monoclonal Antibody (SPM348)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P46527
Other Accession 1027, 238990
Reactivity Human, Mouse, Rat, Monkey
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names SPM348
Calculated MW 25-26kDa
Additional Information
Gene ID 1027
Other Names Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1, CDKN1B, KIP1
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions p27Kip1 (Mitotic Inhibitor/Suppressor Protein) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIP1
Function Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Cellular Location Nucleus. Cytoplasm. Endosome. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK- mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen- activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89 Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity).
Tissue Location Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney
Research Areas
Citations (0)

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This MAb recognizes a 27kDa protein, identified as the p27Kip1, a cell cycle regulatory mitotic inhibitor. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. p27Kip1 functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF- induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. This MAb is excellent for staining of formalin-fixed tissues.


Fredersdorf S et. al. Proc Natl Acad Sci 1997;94:6380-5

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$ 324.00
Cat# AH11005
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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