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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - Without BSA and Azide   

Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - Without BSA and Azide

Mouse Monoclonal Antibody [Clone CHGA/765 ]

  • IHC -  Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - Without BSA and Azide AH11087
    Formalin-fixed, paraffin-embedded human Pancreas stained with Chromogranin A Monoclonal Antibody (CHGA/765)
  • IHC -  Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - Without BSA and Azide AH11087
    Formalin-fixed, paraffin-embedded human Parathyroid stained with Chromogranin A Monoclonal Antibody (CHGA/765)
  • IHC -  Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - Without BSA and Azide AH11087
    Formalin-fixed, paraffin-embedded human Adrenal Gland stained with Chromogranin A Monoclonal Antibody (CHGA/765)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10645
Other Accession 1113, 150793
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names CHGA/765
Calculated MW 68-75kDa
Additional Information
Gene ID 1113
Other Names Chromogranin-A, CgA, Pituitary secretory protein I, SP-I, Vasostatin-1, Vasostatin I, Vasostatin-2, Vasostatin II, EA-92, ES-43, Pancreastatin, SS-18, WA-8, WE-14, LF-19, AL-11, GV-19, GR-44, ER-37, CHGA
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas. Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
Cellular Location Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions.
Tissue Location GE-25 is found in the brain.
Research Areas
Citations (0)

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Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.


Konecki DS et. al. J Biol Chem 1987;262:17026-30. | Lloyd RV et. al. Am J Pathol 1988; 130:296-304

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$ 354.00
$ 484.00
Cat# AH11087
(40 western blots)
Availability: 2-3 days
Bulk Size
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