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Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone CHGA/777 ]

     
  • IHC -  Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - With BSA and Azide AH11089-20
    Formalin-paraffin human Pheochromocytoma stained with Chromogranin A MAb (CHGA/777)
    detail
  • WB -  Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - With BSA and Azide AH11089-20
    Western Blot of human Panc-1 Cell Lysate Chromogranin A MAb (CHGA/777)
    detail
  • IHC -  Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - With BSA and Azide AH11089-20
    Formalin-fixed, paraffin-embedded human Pancreas stained with Chromogranin A Monoclonal Antibody (CHGA/777)
    detail
  • IHC -  Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - With BSA and Azide AH11089-20
    Formalin-fixed, paraffin-embedded human Adrenal Gland stained with Chromogranin A Monoclonal Antibody (CHGA/777)
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF, FC
Primary Accession P10645
Other Accession 1113, 150793
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names CHGA/777
Calculated MW 68-75kDa
Additional Information
Gene ID 1113
Other Names Chromogranin-A, CgA, Pituitary secretory protein I, SP-I, Vasostatin-1, Vasostatin I, Vasostatin-2, Vasostatin II, EA-92, ES-43, Pancreastatin, SS-18, WA-8, WE-14, LF-19, AL-11, GV-19, GR-44, ER-37, CHGA
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHGA
Function [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
Cellular Location [Serpinin]: Secreted {ECO:0000250|UniProtKB:P26339}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P26339}. Note=Pyroglutaminated serpinin localizes to secretory vesicle. {ECO:0000250|UniProtKB:P26339}
Tissue Location Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Detected in urine (at protein level) (PubMed:37453717).
Research Areas
Citations (0)
citation

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Background

Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

References

Schmid, K.W., et al. 1993. Chromogranin A, secretogranin II and vasoactive intestinal peptide in phaeochromocytomas and ganglioneuromas. Histopathology 22: 527-533. |

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$ 219.00
$ 499.00
Cat# AH11089-20
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