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CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone CPS1/1022 ]

  • IHC -  CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Antibody - With BSA and Azide AH11117
    Formalin-fixed, paraffin-embedded human Hepatocellular Carcinoma stained with CPS1 Monoclonal Antibody (CPS1/1022).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P31327
Other Accession 1373, 149252
Reactivity Human, Dog
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1
Clone Names CPS1/1022
Calculated MW ~165kDa
Additional Information
Gene ID 1373
Other Names Carbamoyl-phosphate synthase [ammonia], mitochondrial,, Carbamoyl-phosphate synthetase I, CPSase I, CPS1
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPS1
Function Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
Cellular Location Mitochondrion. Nucleus, nucleolus
Tissue Location Primarily in the liver and small intestine.
Research Areas
Citations (0)

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This MAb recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.ĀDeficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.


Haraguchi, Y., et al. 1991. Cloning and sequence of a cDNA encoding human carbamyl phosphate synthetase I: molecular analysis of hyperam- monemia. Gene 107: 335-340. | Ramos-Vara, J.A., et al. Histochem 2002; J. 34: 397-401. | Fan, Z., et al. Mod. Pathol 2003; 16: 137-144, 2003. |

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$ 124.00
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$ 454.00
Cat# AH11117
(40 western blots)
Availability: 2-3 days
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