CD21 / CR2 / C3d-Receptor / EBV-Receptor Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone FR5A10 ]
|Application ||IHC-F, IF, FC|
|Other Accession||1380, 445757|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Complement receptor type 2, Cr2, Complement C3d receptor, Epstein-Barr virus receptor, EBV receptor, CD21, CR2, C3DR|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD21 / CR2 / C3d-Receptor / EBV-Receptor Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU (PubMed:7753047). Participates in B lymphocytes activation (PubMed:7753047).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen|
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Provided below are standard protocols that you may find useful for product applications.
Recognizes a protein of 140kDa, which is identified as the complement receptor 2 (CR2)/CD21. Its epitope is located in 5-8 short consensus repeats (SCRs). This MAb is highly specific to CR2 and shows no cross-reaction with CR1. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. MAb FR5A10 can be used for EBV receptor studies, interactions between B and T cells especially through CD23, human complement receptor (CR2) studies and IFN-alpha receptor studies.
Schlossman SF et al. eds Leukocyte Typing V, p516-522, Oxford University Press, Oxford, 1995. | Aubry JP et al.In Schlossman SF et al eds. Leukocyte Typing V, p535-536, Oxford University Press, Oxford, 1995
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