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AFP (Alpha Fetoprotein) (Hepatocellular/Germ Cell Tumor Marker) Antibody - Without BSA and Azide

Mouse Monoclonal Antibody [Clone MBS-12 ]

  • IHC -  AFP (Alpha Fetoprotein) (Hepatocellular/Germ Cell Tumor Marker) Antibody - Without BSA and Azide AH11149
    Formalin-fixed, paraffin-embedded human Fetal Liver stained with AFP Monoclonal Antibody (MBS-12).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02771
Other Accession 174, 518808
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names MBS-12
Calculated MW 70kDa
Additional Information
Gene ID 174
Other Names Alpha-fetoprotein, Alpha-1-fetoprotein, Alpha-fetoglobulin, AFP, HPAFP
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions AFP (Alpha Fetoprotein) (Hepatocellular/Germ Cell Tumor Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AFP
Synonyms HPAFP
Function Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.
Cellular Location Secreted.
Tissue Location Plasma. Synthesized by the fetal liver and yolk sac
Research Areas
Citations (0)

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It recognizes an oncofetal glycoprotein with a single chain of 70kDa, which is identified as alpha fetoprotein (AFP). This MAb is highly specific to AFP and shows no cross-reaction with other oncofetal antigens or serum albumin. The yolk sac and the liver produce AFP during fetal life. AFP expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the AFP and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. AFP is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of AFP in amniotic fluid is used to measure renal loss of protein to screen for spinal bifida and anencephaly.Ā


Stefanova, I., Horejs�, V., Kristofov�, H., Angelisov�, P., Zizkovský, V. and Hilgert, I. 1988. Monoclonal antibodies against human α-fetoprotein. Exploitation of an unusual calcium-dependent interaction with the antigen for analytical and preparative purposes. J. Immunol. Methods 111: 67-73. | Lafuste, P., et al. 2002. α-fetoprotein gene expression in early and full-term human trophoblast. Placenta 23: 600-612

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$ 354.00
$ 484.00
Cat# AH11149
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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