IgA Secretory Component / ECM1 Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone ECM1/792 ]
|Application ||IHC, IF, FC|
|Other Accession||1893, 81071|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Extracellular matrix protein 1, Secretory component p85, ECM1|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||IgA Secretory Component / ECM1 Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This MAb reacts with a reduction-resistant epitope present in both free and SIgA bound Secretory Component. It does not react with the cell lines lacking secretory component. The antibody is useful for studying the distribution and level of both free and bound secretory component. Secretory component is differentially expressed in epithelium, and the antibody is a popular marker for identifying subpopulations of epithelial cells and epithelial differentiation. The Secretory component antibody is a useful research tool for studying mucosal immunity, inflammation, remodeling, differentiation and tumorigenesis, all processes associated with differential secretory component expression.
K�hn, L.C. and Kraehenbuhl, J.P. 1980. Role of secretory component, a secreted of IgA dimer by epithelial cells. J. Biol. Chem. 254: 11072-11081
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.