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TRIM29 (Lung Squamous Cell Carcinoma Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone TRIM29/1042 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, FC |
|---|---|
| Primary Accession | Q14134 |
| Other Accession | 23650, 504115 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG2b, kappa |
| Clone Names | TRIM29/1042 |
| Calculated MW | 66kDa |
| Gene ID | 23650 |
|---|---|
| Other Names | Tripartite motif-containing protein 29, Ataxia telangiectasia group D-associated protein, TRIM29, ATDC |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | TRIM29 (Lung Squamous Cell Carcinoma Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM29 |
|---|---|
| Synonyms | ATDC |
| Function | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. |
| Cellular Location | Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments |
| Tissue Location | Expressed in placenta, prostate and thymus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
It recognizes a 66kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies.
References
Kosaka Y, et al. Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. Ann Surg Oncol. 14(9): 2543-9. 2007. | Ring BZ, et al. A novel five-antibody immunohistochemical test for sub-classification of lung carcinoma. Mod Pathol. 22(8): 1032-43. 2009
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