|Application ||IHC, IF, FC|
|Other Accession||248, 284255, 333509, 370099, 75431, P05187, P09923, P10696|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Alkaline phosphatase, tissue-nonspecific isozyme, AP-TNAP, TNSALP, 188.8.131.52, Alkaline phosphatase liver/bone/kidney isozyme, ALPL|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Alkaline Phosphatase (Intestinal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This isozyme may play a role in skeletal mineralization.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
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There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Moss, D.W. 1987. Diagnostic aspects of alkaline phosphatase and its isoenzymes. Clin. Biochem. 20: 225-230. | Griffin, C.A., et al. 1987. Human placental and intestinal alkaline phosphatase genes map to 2q34-q37. Am. J. Hum. Genet. 41: 1025-1034
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