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Placental Alkaline Phosphatase (PLAP) (Germ Cell Tumor Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone SPM593 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, IF, FC |
|---|---|
| Primary Accession | P05187 |
| Other Accession | 250, 284255 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG2b, kappa |
| Clone Names | SPM593 |
| Calculated MW | 70kDa |
| Gene ID | 250 |
|---|---|
| Other Names | Alkaline phosphatase, placental type, 3.1.3.1, Alkaline phosphatase Regan isozyme, Placental alkaline phosphatase 1, PLAP-1, ALPP, PLAP |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Placental Alkaline Phosphatase (PLAP) (Germ Cell Tumor Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ALPP (HGNC:439) |
|---|---|
| Function | Alkaline phosphatase that can hydrolyze various phosphate compounds. |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor |
| Tissue Location | Detected in placenta (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Reacts with a 70kDa membrane-bound isozyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase. Anti-PLAP reacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease.Ā
References
Wick, MR, et al. 1987; Hum Pathol. 18(9):946-54
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