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>   home   >   Products   >   Primary Antibodies   >   Immunology   >    Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) Antibody - With BSA and Azide   

Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone ALPP/238 ]

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05187
Other Accession 250, 284255
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names ALPP/238
Calculated MW 70kDa
Additional Information
Gene ID 250
Other Names Alkaline phosphatase, placental type,, Alkaline phosphatase Regan isozyme, Placental alkaline phosphatase 1, PLAP-1, ALPP, PLAP
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PLAP
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Location Detected in placenta (at protein level).
Research Areas
Citations (0)

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PLAP is a tissue specific, trophoblast-derived, 70kDa, glycosyl-phosphatidylinositol (GPI)-anchored, dimeric, Zn2+ metallo glycoprotein that catalyzes the hydrolysis of phosphomonoesters into an inorganic phosphate and an alcohol. It is present in the placenta and serum of pregnant women and in high frequency in gynecological and testicular cancers and in lower frequency in other tumors. The three tissue-specific APā€™s in humans, PLAP, germ cell AP (GCAP) and intestinal AP, are 90-98% homologous. Non-tissue specific AP is found in kidney, liver and bone. This MAb binds equally well to all common allelic variants (S, F, FS and I) of PLAP as to AP from normal human testis. This MAb can be used both as coating as well as tracer antibody in the same ELISA to detect PLAP in serum of S, F, FS and I phenotypes.


Millan J.L. et. al., Antigenic determinants of human placental and testicular alkaline phosphatase as mapped by monoclonal antibodies. Eur. J. Biochem. 136: 1-12, (1983). | Riklund K.E. et. al., Experimental radio-immunotherapy of HeLa tumors in nude mice with 131I-labeled monoclonal antibodies. Anticancer Research, 1990, 10:379-84

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$ 124.00
$ 324.00
$ 454.00
Cat# AH11255
(40 western blots)
Availability: 2-3 days
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