Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) Antibody
Mouse Monoclonal Antibody [Clone PL8-F6 ]
|Application ||IHC-F, IF, FC|
|Other Accession||250, 284255|
|Isotype||Mouse / IgG2b, kappa|
|Other Names||Alkaline phosphatase, placental type, 18.104.22.168, Alkaline phosphatase Regan isozyme, Placental alkaline phosphatase 1, PLAP-1, ALPP, PLAP|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor.|
|Tissue Location||Detected in placenta (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Reacts with a 70kDa membrane-bound isozyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase. Anti-PLAP reacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease.Ā
Fishman WH, et al. Cancer Res 28:150-154, 1968. | Ho DM, et al. Cancer 70: 1577-1584, 1992. | Loke Y, et al. Int J Cancer 25:459-461, 1980. | Millan JL and Manes T. Proc Natl Acad Sci USA 85: 3024-3028, 1988. |
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