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Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) Antibody - Without BSA and Azide

Mouse Monoclonal Antibody [Clone PL8-F6 ]

     
  • IHC -  Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) Antibody - Without BSA and Azide AH11264
    Formalin-fixed, paraffin-embedded human Placenta stained with PLAP Monoclonal Antibody (PL8-F6).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-F, IF, FC
Primary Accession P05187
Other Accession 250, 284255
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2b, kappa
Clone Names PL8-F6
Calculated MW 70kDa
Additional Information
Gene ID 250
Other Names Alkaline phosphatase, placental type, 3.1.3.1, Alkaline phosphatase Regan isozyme, Placental alkaline phosphatase 1, PLAP-1, ALPP, PLAP
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALPP
Synonyms PLAP
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Location Detected in placenta (at protein level).
Research Areas
Citations (0)

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Background

Reacts with a 70kDa membrane-bound isozyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase. Anti-PLAP reacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease.Ā

References

Fishman WH, et al. Cancer Res 28:150-154, 1968. | Ho DM, et al. Cancer 70: 1577-1584, 1992. | Loke Y, et al. Int J Cancer 25:459-461, 1980. | Millan JL and Manes T. Proc Natl Acad Sci USA 85: 3024-3028, 1988. |

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$ 354.00
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Cat# AH11264
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