CD15 / FUT4 (Reed-Sternberg Cell Marker) Antibody
Mouse Monoclonal Antibody [Clone Leu-M1; same as MMA ]
|Application ||IHC, IF, FC|
|Other Accession||2526, 654379|
|Isotype||Mouse / IgM, kappa|
|Clone Names||Leu-M1; same as MMA|
|Calculated MW||~220kDa (Glycoprotein)|
|Other Names||Alpha-(1, 3)-fucosyltransferase 4, 2.4.1.-, ELAM-1 ligand fucosyltransferase, Fucosyltransferase 4, Fucosyltransferase IV, Fuc-TIV, FucT-IV, Galactoside 3-L-fucosyltransferase, FUT4, ELFT, FCT3A|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD15 / FUT4 (Reed-Sternberg Cell Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi|
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Provided below are standard protocols that you may find useful for product applications.
CD15 plays a role in mediating phagocytosis, bactericidal activity, and chemotaxis. It is present on >95% of granulocytes including neutrophils and eosinophils and to a lesser degree on monocytes. In addition, CD15 is expressed in Reed-Sternberg cells and some epithelial cells. CD15 antibody is very useful in the identification of Hodgkin s disease. CD15 is occasionally expressed in large cell lymphomas of both B and T phenotypes which otherwise have a quite distinct histological appearance.
Hanjan SN et. al. Clinical Immunology & Immunopathology, 1982;23(2):172-88. | Hsu et. al. Amer J Clin Pathol 82: 29, 1984.3. Pinkus et. al. Am J Pathol 119: 244, 1985. |
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