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EMI1 (Early Mitotic Inhibitor-1) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone EMI1/1176 ]

  • IHC -  EMI1 (Early Mitotic Inhibitor-1) Antibody - With BSA and Azide AH11284
    Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with EMI1 Monoclonal Antibody (EMI1/1176).
  • IHC -  EMI1 (Early Mitotic Inhibitor-1) Antibody - With BSA and Azide AH11284
    Formalin-fixed, paraffin-embedded human Ovarian carcinoma stained with EMI1 Monoclonal Antibody (EMI1/1176).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UKT4
Other Accession 26271, 520506
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names EMI1/1176
Calculated MW 56kDa
Additional Information
Gene ID 26271
Other Names F-box only protein 5, Early mitotic inhibitor 1, FBXO5, EMI1, FBX5
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions EMI1 (Early Mitotic Inhibitor-1) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXO5
Synonyms EMI1, FBX5
Function Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.
Cellular Location Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle
Research Areas
Citations (0)

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It recognizes a 56kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.


Reimann, J.D., et al. 2001. Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Cell 105: 645-655. |

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$ 124.00
$ 324.00
$ 454.00
Cat# AH11284
(40 western blots)
Availability: 2-3 days
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