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GFAP (Astrocyte & Neural Stem Cell Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone ASTRO/789 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, FC |
|---|---|
| Primary Accession | P14136 |
| Other Accession | 2670, 514227 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Chicken, Cow |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1 |
| Clone Names | ASTRO/789 |
| Calculated MW | ~50kDa |
| Gene ID | 2670 |
|---|---|
| Other Names | Glial fibrillary acidic protein, GFAP, GFAP |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | GFAP (Astrocyte & Neural Stem Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GFAP |
|---|---|
| Function | GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
| Cellular Location | Cytoplasm. Note=Associated with intermediate filaments |
| Tissue Location | Expressed in cells lacking fibronectin. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This MAb recognizes a protein of ~50kDa which is identified as Glial Fibrillary Acidic Protein (GFAP). It shows no cross-reaction with other intermediate filament proteins. GFAP is specifically found in astroglia. GFAP is a very popular marker for localizing benign astrocyte and neoplastic cells of glial origin in the central nervous system. Antibody to GFAP is useful in differentiating primary gliomas from metastatic lesions in the brain and for documenting astrocytic differentiation in tumors outside the CNS.
References
McLendon, R.E. and Bigner, D.D. 1994. Immunohistochemistry of the glial fibrillary acidic protein: basic and applied considerations. Brain Pathol. 4: 221-228. | Eng, L.F. and Ghirnikar, R.S. 1994. GFAP and astrogliosis. Brain Pathol. 4: 229-237. |
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