CD57 / B3GAT1 (Natural Killer Cell Marker) Antibody - Without BSA and Azide
Mouse Monoclonal Antibody [Clone HNK-1 + NK-1 ]
|Application ||IHC, IF|
|Other Accession||27087, 381050|
|Isotype||Mouse / IgM's|
|Clone Names||HNK-1 + NK-1|
|Other Names||Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1, 188.8.131.52, Beta-1, 3-glucuronyltransferase 1, Glucuronosyltransferase P, GlcAT-P, UDP-GlcUA:glycoprotein beta-1, 3-glucuronyltransferase, GlcUAT-P, B3GAT1, GLCATP|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD57 / B3GAT1 (Natural Killer Cell Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group (By similarity).|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Mainly expressed in the brain.|
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Provided below are standard protocols that you may find useful for product applications.
Anti-CD57 marks a subset of lymphocytes known as natural killer (NK) cells. Follicular center cell lymphomas often contain many NK cells within the neoplastic follicles. Anti-CD57 also stains neuroendocrine cells and their derived tumors, including carcinoid tumor and medulloblastoma. Anti-CD57 can also be useful in separating type B3 thymoma from thymic carcinoma when combined with a panel that includes antibodies against GLUT1, CD5, and CEA.
Abo T et. al. J Immunol, 1982, 129(4):1758-61. | Abo T et al. J Immunology, 1982, 129:1752-7
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