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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >    Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Antibody   

Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Antibody

Mouse Monoclonal Antibody [Clone GPC3/863 ]

  • IHC -  Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Antibody AH11319
    Formalin-fixed, paraffin-embedded human Hepatocellular Carcinoma stained with Glypican-3 Monoclonal Antibody (GPC3/863)
  • IHC -  Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Antibody AH11319
    Formalin-fixed, paraffin-embedded Rat Lung stained with Glypican-3 Monoclonal Antibody (GPC3/863)
  • IHC -  Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Antibody AH11319
    Formalin-fixed, paraffin-embedded Rat Heart stained with Glypican-3 Monoclonal Antibody (GPC3/863)
  • IHC -  Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Antibody AH11319
    Formalin-fixed, paraffin-embedded human Melanoma stained with Glypican-3 Monoclonal Antibody (GPC3/863)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51654
Other Accession 2719, 644108
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names GPC3/863
Calculated MW 67kDa
Additional Information
Gene ID 2719
Other Names Glypican-3, GTR2-2, Intestinal protein OCI-5, MXR7, Secreted glypican-3, GPC3, OCI5
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPC3
Synonyms OCI5
Function Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side
Tissue Location Highly expressed in lung, liver and kidney.
Research Areas
Citations (0)

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Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilm s tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression is also found in some types of embryonal tumors, such as Wilm s tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.


Yan, B., et al. 2011. Expression and clinicopathologic significance of glypican 3 in hepatocellular carcinoma. Ann. Diagn. Pathol. 15: 162-169. |

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$ 324.00
Cat# AH11319
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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