AMP Deaminase, Isoform E (AMPD3) (Erythroid Marker) Antibody
Mouse Monoclonal Antibody [Clone AMPD3/901 ]
|Application ||IHC-F, IF, FC, ICC|
|Other Accession||272, 501890|
|Isotype||Mouse / IgG2b, kappa|
|Other Names||AMP deaminase 3, 18.104.22.168, AMP deaminase isoform E, Erythrocyte AMP deaminase, AMPD3|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||AMP Deaminase, Isoform E (AMPD3) (Erythroid Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||AMP deaminase plays a critical role in energy metabolism.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
It recognizes a protein of ~90kDa, which is identified as Adenosine Monophosphate Deaminase, isoform E (AMPD3). It has 767 amino acids and is assigned an EC 22.214.171.124. It is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. AMPD3 gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. This MAb shows reactivity with cells of the erythroid lineage at all stages of maturation in the peripheral blood, bone marrow, and fetal liver. Non-erythroid lineages are negative by flow cytometry. This MAb is useful in the diagnosis of erythroleukemia, identification of bone marrow erythroid precursors, gating erythroid nucleated precursor cells from malignant cells in bone marrow specimens.
Sabina RL, Waldenstrm A, Ronquist G. The contribution of Ca+ calmodulin activation of human erythrocyte AMP deaminase (isoform E) to the erythrocyte metabolic dysregulation of familial phosphofructokinase deficiency. Haematologica. 2006;91(5):652-5
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.