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GnRH-Receptor / LH-RH Receptor Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone F1G4; same as GNRH03 ]

  • IHC -  GnRH-Receptor / LH-RH Receptor Antibody - With BSA and Azide AH11338
    Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with GnRH-Receptor Monoclonal Antibody (F1G4)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P30968
Other Accession 2798 (GNRHR) and 3973 (LHCGR), 407587 (GNRHR) 468490 (LHCGR)
Reactivity Human, Rat, Rabbit, Pig
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names F1G4; same as GNRH03
Calculated MW 54-60kDa
Additional Information
Gene ID 2798
Other Names Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R, GNRHR, GRHR
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions GnRH-Receptor / LH-RH Receptor Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GRHR
Function Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Pituitary, ovary, testis, breast and prostate but not in liver and spleen
Research Areas
Citations (0)

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Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.


Karande AA; Rajeshwari K; Schol DJ; Hilgers JH. Establishment of immunological probes to study human gonadotropin-releasing hormone receptors. Molecular and Cellular Endocrinology, 1995, 114(1-2):51-6

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$ 124.00
$ 324.00
$ 454.00
Cat# AH11338
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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