|Application ||IHC, IF, FC|
|Other Accession||2798 (GNRHR) and 3973 (LHCGR), 407587 (GNRHR) 468490 (LHCGR)|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R, GNRHR, GRHR|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||GnRH-Receptor / LH-RH Receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Pituitary, ovary, testis, breast and prostate but not in liver and spleen|
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Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.
Pidoux, G., et al. 2007. Biochemical characterization and modulation of LH/CG-receptor during human trophoblast differentiation. J. Cell. Physiol. 212: 26-35
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