Glycophorin A / CD235a (Erythrocyte Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone SPM599 ]
|Application ||IHC, IF, FC|
|Other Accession||2993, 2994, 434973, 654368|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Glycophorin-A, MN sialoglycoprotein, PAS-2, Sialoglycoprotein alpha, CD235a, GYPA, GPA|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Glycophorin A / CD235a (Erythrocyte Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Note=Appears to be colocalized with SLC4A1|
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Recognizes a sialoglycoprotein of 39kDa, identified as glycophorin A (GPA). It is present on red blood cells (RBC) and erythroid precursor cells. It has been shown that glycophorin acts as the receptor for Sandei virus and parvovirus. Glycophorins A (GPA) and B (GPB), which are single, trans-membrane sialoglycoproteins. GPA is the carrier of blood group M and N specificities, while GPB accounts for S and U specificities. GPA and GPB provide the cells with a large mucin like surface and it has been suggested this provides a barrier to cell fusion, so minimizing aggregation between red blood cells in the circulation.
Andersson, L.C., et al. 1979. Glycophorin A as a cell surface marker of early erythroid differentiation in acute leukemia. Int. J. Cancer 23: 717-720. | Liszka, K., et al., 1983. Glycophorin A expression in malignant hematopoiesis. Am. J. Hematol. 15: 219-226. |
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