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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >    Granzyme B (NK/T-Cell Lymphoma Marker) Antibody - Without BSA and Azide   

Granzyme B (NK/T-Cell Lymphoma Marker) Antibody - Without BSA and Azide

Rabbit Polyclonal Antibody [Clone ]

  • WB -  Granzyme B (NK/T-Cell Lymphoma Marker) Antibody - Without BSA and Azide AH11385
    Western Blot Analysis of human Stomach Lysate using Granzyme B Polyclonal Antibody (Rabbit)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10144
Other Accession 3002, 1051
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit / IgG
Clone Names
Calculated MW 29-32kDa
Additional Information
Gene ID 3002
Other Names Granzyme B,, C11, CTLA-1, Cathepsin G-like 1, CTSGL1, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, Fragmentin-2, Granzyme-2, Human lymphocyte protein, HLP, SECT, T-cell serine protease 1-3E, GZMB, CGL1, CSPB, CTLA1, GRB
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Granzyme B (NK/T-Cell Lymphoma Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CGL1, CSPB, CTLA1, GRB
Function This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Cellular Location Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells
Research Areas
Citations (0)

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Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'non-self' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkinā€™s Disease.


Shresta, S., et al. 1995. Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells. Proc. Natl. Acad. Sci. USA 92: 5679-5683

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$ 354.00
$ 484.00
Cat# AH11385
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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