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Mouse Monoclonal Antibody [Clone SPM417 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, IF, FC |
|---|---|
| Primary Accession | P01889 |
| Other Accession | 3105, 181244, 654404, 77961, P30443, P30499 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG2a, kappa |
| Clone Names | SPM417 |
| Calculated MW | kDa |
| Gene ID | 3106 |
|---|---|
| Other Names | HLA class I histocompatibility antigen, B-7 alpha chain, MHC class I antigen B*7, HLA-B, HLAB |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | HLA-Aw32 & HLA-A25 (MHC I) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HLA-B |
|---|---|
| Synonyms | HLAB |
| Function | Involved in the presentation of foreign antigens to the immune system. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This MAb reacts with cells bearing HLA-A25 or HLA-Aw32 antigens. In addition, a reaction was observed with a cell of phenotype A2, Aw31; B17, Bw49. HLA-A, with HLA-B and HLA-C, belongs to major histocompatibility complex (MHC) class I antigens and expresses constitutively on all nucleated cells. HLA system comprises closely linked genes controlling highly polymorphic proteins involved in the presentation of peptides to the T-cell receptor, inhibition of NK cell cytotoxicity, and rejection of tissue allotransplantation. Specific alleles at HLA loci are associated with diseases. This MAb is specifically applicable for typing peripheral T cells for the antigens HLA-A25 and HLA-Aw32.
References
Vilella R et al. Monoclonal antibody against HLA-Aw32 + A25. Is HLA-Aw32 an allele with no unique antigenic determinant? Hum Immunol 1983, 6(1):53-62. |
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