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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Heparan Sulfate Proteoglycan (Large) / Perlecan Antibody - With BSA and Azide   

Heparan Sulfate Proteoglycan (Large) / Perlecan Antibody - With BSA and Azide

Rat Monoclonal Antibody [Clone A7L6 ]

  • IHC -  Heparan Sulfate Proteoglycan (Large) / Perlecan Antibody - With BSA and Azide AH11471
    Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with Heparan Sulfate Monoclonal Antibody (A7L6).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P98160
Other Accession 3339, 562227
Reactivity Human, Mouse, Monkey, Pig, Cow, Fish
Host Rat
Clonality Monoclonal
Isotype Rat / IgG2a, kappa
Clone Names A7L6
Calculated MW >400kDa
Additional Information
Gene ID 3339
Other Names Basement membrane-specific heparan sulfate proteoglycan core protein, HSPG, Perlecan, PLC, Endorepellin, LG3 peptide, HSPG2
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Heparan Sulfate Proteoglycan (Large) / Perlecan Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSPG2
Function Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.
Cellular Location Secreted, extracellular space, extracellular matrix, basement membrane
Tissue Location Found in the basement membranes.
Research Areas
Citations (0)

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This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.


Folkvord et. al., J Histochem Cytochem, 1989; 37:105-113. | Couchman et. al., Matrix, 1989; 9:311-321. | Horiguchi et. al., J Histochem Cytochem, 1989; 37:961-970. | Ljubimov et. al., Int J Cancer, 1992; 50:562-566. | Guelstein et. al., Int J Cancer, 1993; 53:269-277. | Ljubimov et. al., Lab Invest, 1995; 72:461-473

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$ 124.00
$ 324.00
$ 454.00
Cat# AH11471
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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