|Application ||IF, FC|
|Other Accession||3458, 856|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Interferon gamma, IFN-gamma, Immune interferon, IFNG|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Interferon gamma (IFNG) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.|
|Tissue Location||Released primarily from activated T lymphocytes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Recognizes a protein of 20-25kDa, identified as human interferon. This MAb is specific to human IFN- and recognizes both recombinant and native human IFN-γ. It does not neutralize the activity of IFN-. T lymphocytes and NK cells mainly produce IFN-. It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses, including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. It has weak anti-viral and anti-proliferative activity, and potentiates the antiviral and anti-tumor effects of IFN- (type I interferon).
Vilcek J. Forty years of interferon, forty years of cytokines. Cytokine Growth Factor Rev 1997,8(4):239 | Farrar MA and Schreiber RD. The molecular cell biology of interferon-gamma and its receptor. Annu Rev Immunol 1993, 11:571-611 | Vilcek J et al. Induction of human interferon gamma with phorbol esters and phytohemagglutinin. Methods Enzymol 1986,119:48-54 |
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.