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IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide

Mouse Monoclonal Antibody [Clone ICO-30 ]

  • IHC -  IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide AH11526
    Formalin-fixed, paraffin-embedded human Tonsil stained with IgM Monoclonal Antibody (ICO-30)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01871
Other Accession 3507, 510635, P20769
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names ICO-30
Calculated MW 50-75kDa
Additional Information
Other Names Ig mu chain C region, IGHM
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane- bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts.
Cellular Location Isoform 1: Secreted. Note=During differentiation, B-lymphocytes switch from expression of membrane- bound IgM to secretion of IgM
Research Areas
Citations (0)

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Recognizes a protein of 75kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkinā€™s lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.


Baryshnikov AIu. Gematol Transfuziol. 1990 Aug;35(8):4-7. | Martinova al., In: Problems medical biotechnology and immunological infection diseases. Vol 11, 182-186, 1996. | Baryshnikov A, and Tonevitsky A, Monoclonal antibodies in laboratory and clinic. Thesis p212, 1997

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$ 354.00
$ 484.00
Cat# AH11526
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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