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>   home   >   Products   >   Primary Antibodies   >   Immunology   >    Lambda Light Chain (B-Cell Marker) Antibody   

Lambda Light Chain (B-Cell Marker) Antibody

Mouse Monoclonal Antibody [Clone HP6054 ]

     
  • IHC -  Lambda Light Chain (B-Cell Marker) Antibody AH11548-7
    Formalin-fixed, paraffin-embedded human Tonsil stained with Lambda Light Chain Monoclonal Antibody (HP6054).
  • WB -  Lambda Light Chain (B-Cell Marker) Antibody AH11548-7
    Western Blot of human Intestinal Lysateusing Lambda Light Chain Monoclonal Antibody (HP6054).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF, FC
Primary Accession P01701
Other Accession 3535, 3546, 449585, P01842
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names HP6054
Calculated MW ~22.5kDa
Additional Information
Other Names Ig lambda chain V-I region NEW, LV103
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Lambda Light Chain (B-Cell Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IGLV1-51 {ECO:0000303|PubMed:11872955, ECO:0000303|Ref.7}
Function V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
Cellular Location Secreted. Cell membrane
Research Areas
Citations (0)

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Background

This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

References

Reimer et al. Hybridoma 3: 263, 1984. |

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$ 324.00
Cat# AH11548-7
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