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Androgen Receptor (Marker of Androgen Dependence) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone AR441 + DHTR/882 ]

     
  • IHC -  Androgen Receptor (Marker of Androgen Dependence) Antibody - With BSA and Azide AH11601-20
    Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Androgen Receptor Monoclonal Antibody (AR441 + DHTR/882).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, IF
Primary Accession P10275
Other Accession 367, 496240
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG's
Clone Names AR441 + DHTR/882
Calculated MW 110kDa
Additional Information
Gene ID 367
Other Names Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Androgen Receptor (Marker of Androgen Dependence) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AR
Synonyms DHTR, NR3C4
Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Cellular Location Nucleus. Cytoplasm Note=Detected at the promoter of target genes (PubMed:25091737) Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1.
Tissue Location [Isoform 2]: Mainly expressed in heart and skeletal muscle.
Research Areas
Citations (0)
citation

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Background

Recognizes a protein of 110kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin.ĀThis MAb is superb for staining of formalin/paraffin tissues.

References

J�nne OA, et al. Androgen receptor and mechanism of androgen action. Ann Med 1993; 25:8

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$ 219.00
$ 499.00
Cat# AH11601-20
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