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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Integrin Antibodies   >    CD41a / Integrin alpha2b (Platelet Marker) Antibody - With BSA and Azide   

CD41a / Integrin alpha2b (Platelet Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone ITGA2B/1036 ]

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IF, FC
Primary Accession P08514
Other Accession 3674, 411312
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names ITGA2B/1036
Calculated MW 90kDa
Additional Information
Gene ID 3674
Other Names Integrin alpha-IIb, GPalpha IIb, GPIIb, Platelet membrane glycoprotein IIb, CD41, Integrin alpha-IIb heavy chain, Integrin alpha-IIb light chain, form 1, Integrin alpha-IIb light chain, form 2, ITGA2B, GP2B, ITGAB
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD41a / Integrin alpha2b (Platelet Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGA2B
Synonyms GP2B, ITGAB
Function Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Cellular Location Membrane; Single-pass type I membrane protein.
Tissue Location Isoform 1 and isoform 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. Not detected in Jurkat, nor in U937 cell lines (PubMed:2351656). Isoform 3 is expressed in prostate adenocarcinoma, as well as in several erythroleukemia, prostate adenocarcinoma and melanoma cell lines, including PC-3, DU- 145, HEL, WM983A, WM983B and WM35. Not detected in platelets, nor in normal prostate (at protein level) (PubMed:9809974)
Research Areas
Citations (0)
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Background

Reacts with a calcium-dependent complex of CD41/CD61, a dimer of 90kDa and 140kDa present on the membrane of normal platelets and megakaryocytes. CD41/CD61 is also known as platelet glycoprotein GPIIb/GPIIIa or integrin IIa/3. This complex is the receptor of fibrinogen, fibronectin and von Willebrand factor, and mediates platelet adhesion and aggregation.

References

McMichael AJ et al. (eds) Leukocyte Typing III, Oxford University Press, Oxford, 1987. | Schlossman S. et al. (eds) Leukocyte Typing V, Oxford University Press, Oxford, 1995. | Smith JW et al. Interaction of integrins v3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites. J Biol Chem 1990, 265(21):12267-12271. | Du XP et al. Ligands activate integrin IIb/3 (platelet GPIIb-IIIa). Cell 1991, 65(3):409-416. | Law DA et al. Outside-in integrin signal transduction. IIb/3-(GP IIb/IIIa) tyrosine phosphorylation induced by platelet aggregation. J Biol Chem 1996, 271(18):10811-10815. | Moroi M and Jung SM. Integrin-mediated platelet adhesion. Front Biosci 1998, 3:D719-728

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$ 219.00
$ 499.00
Cat# AH11603-20
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