CD61 / Integrin beta-3 (Platelet Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone 25E11.]
|Application ||IF, FC|
|Other Accession||3690, 218040|
|Isotype||Mouse / IgM, kappa|
|Calculated MW||105kDa & 90kDa|
|Other Names||Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD61, ITGB3, GP3A|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD61 / Integrin beta-3 (Platelet Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.|
|Cellular Location||Cell membrane; Single- pass type I membrane protein. Cell projection, lamellipodium membrane Cell junction, focal adhesion|
|Tissue Location||Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis|
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Provided below are standard protocols that you may find useful for product applications.
Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). The protein detectable is a complex of CD41 and CD61.The apparent molecular weight of the GPIIIa by SDS-PAGE is 105kDa reduced and 90kDa unreduced. Ligands are fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin. Residues 237-248 of GPIIIa or CD61 are critical in adhesive protein binding.Ā
McMichael AJ et al. (eds) Leukocyte Typing III, Oxford University Press, Oxford, 1987. | Schlossman S. et al. (eds) Leukocyte Typing V, Oxford University Press, Oxford, 1995
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