Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody
Mouse Monoclonal Antibody [Clone IVRN/827 ]
|Application ||IHC, IF, FC|
|Other Accession||3713, 516439|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Involucrin, IVL|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.|
|Cellular Location||Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope|
|Tissue Location||Keratinocytes of epidermis and other stratified squamous epithelia|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
It recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120kDa protein. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.
Eckert, R.L. and Green, H. 1986. Structure and evolution of the human involucrin gene. Cell 46: 583-589
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.