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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody - With BSA and Azide   

Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone IVRN/827 ]

  • IHC -  Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody - With BSA and Azide AH11618
    Formalin-fixed, paraffin-embedded human Tonsil stained with Involucrin Monoclonal Antibody (IVRN/827)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P07476
Other Accession 3713, 516439
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names IVRN/827
Calculated MW 66-170kDa
Additional Information
Gene ID 3713
Other Names Involucrin, IVL
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IVL
Function Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
Cellular Location Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope
Tissue Location Keratinocytes of epidermis and other stratified squamous epithelia
Research Areas
Citations (0)

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It recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120kDa protein. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.


Eckert, R.L. and Green, H. 1986. Structure and evolution of the human involucrin gene. Cell 46: 583-589

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$ 124.00
$ 324.00
$ 454.00
Cat# AH11618
(40 western blots)
Availability: 2-3 days
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