Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone IVRN/827 ]
|Application ||IHC, IF, FC|
|Other Accession||3713, 516439|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Involucrin, IVL|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.|
|Cellular Location||Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope|
|Tissue Location||Keratinocytes of epidermis and other stratified squamous epithelia|
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It recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120kDa protein. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.
Eckert, R.L. and Green, H. 1986. Structure and evolution of the human involucrin gene. Cell 46: 583-589
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