Arginase 1 (Hepatocellular Carcinoma Marker) Antibody - Without BSA and Azide
Mouse Monoclonal Antibody [Clone ARG1/1125 + ARG1/1126 ]
|Application ||IHC, IF, FC|
|Other Accession||383, 440934|
|Isotype||Mouse / IgG's|
|Clone Names||ARG1/1125 + ARG1/1126|
|Other Names||Arginase-1, 126.96.36.199, Liver-type arginase, Type I arginase, ARG1|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Arginase 1 (Hepatocellular Carcinoma Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
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Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes, which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle, whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma.
Diez, A., et al. 1994. Immunological identity of the two different molecular mass constitutive subunits of liver arginase. Biol. Chem. Hoppe Seyler 375: 537-541
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