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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin) Antibody   

Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin) Antibody

Mouse Monoclonal Antibody [Clone SPM269 ]

  • IHC -  Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin) Antibody AH11636
    Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with Cytokeratin 6 Monoclonal Antibody (SPM269)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02538
Other Accession 3853-KRT6A, 3854-KRT6B, 286887-KRT6C, 700779, P04259-KRT6B, P48668-KRT6C
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names SPM269
Calculated MW 56kDa
Additional Information
Gene ID 3853
Other Names Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Cytokeratin-6D, CK-6D, Keratin-6A, K6A, Type-II keratin Kb6, Hom s 5, KRT6A, K6A, KRT6D
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT6A
Synonyms K6A, KRT6D
Function Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.
Tissue Location Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath
Research Areas
Citations (0)

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This MAb recognizes a protein of 56kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.


Wetzels RH, et. al. American Journal of Pathology, 1991, 138(3):751-63

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$ 324.00
Cat# AH11636
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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