Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin) Antibody
Mouse Monoclonal Antibody [Clone SPM269 ]
|Application ||IHC, IF, FC|
|Other Accession||3853-KRT6A, 3854-KRT6B, 286887-KRT6C, 700779, P04259-KRT6B, P48668-KRT6C|
|Isotype||Mouse / IgG2a, kappa|
|Other Names||Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Cytokeratin-6D, CK-6D, Keratin-6A, K6A, Type-II keratin Kb6, Hom s 5, KRT6A, K6A, KRT6D|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.|
|Tissue Location||Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath|
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Provided below are standard protocols that you may find useful for product applications.
This MAb recognizes a protein of 56kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.
Wetzels RH, et. al. American Journal of Pathology, 1991, 138(3):751-63
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