Cytokeratin 7 (KRT7) (Glandular and Transitional Epithelial Marker) Antibody
Mouse Monoclonal Antibody [Clone KRT7/903 ]
|Application ||IHC, IF, FC|
|Other Accession||3855, 411501|
|Isotype||Mouse / IgG1|
|Other Names||Keratin, type II cytoskeletal 7, Cytokeratin-7, CK-7, Keratin-7, K7, Sarcolectin, Type-II keratin Kb7, KRT7, SCL|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Cytokeratin 7 (KRT7) (Glandular and Transitional Epithelial Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).|
|Tissue Location||Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus|
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Provided below are standard protocols that you may find useful for product applications.
Cytokeratin 7 is a basic cytokeratin, which is found in most glandular and transitional epithelia but not in the stratified squamous epithelia. Keratin 7 is expressed in the epithelial cells of ovary, lung, and breast but not of colon, prostate, or gastrointestinal tract. Antibody to cytokeratin is useful in distinguishing ovarian carcinomas (keratin 7+) from colon carcinomas (keratin 7-).
Fuchs, E. 1995. Keratins and the skin. Annu. Rev. Cell Dev. Biol. 11:123-153. |
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