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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Cytokeratin 8 (KRT8) Antibody   

Cytokeratin 8 (KRT8) Antibody

Mouse Monoclonal Antibody [Clone KRT8/899 ]

  • IHC -  Cytokeratin 8 (KRT8) Antibody AH11677
    Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with Cytokeratin 8 Monoclonal Antibody (KRT8/899).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05787
Other Accession 3856, 533782, 708445
Reactivity Human, Rabbit, Monkey
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgM, kappa
Clone Names KRT8/899
Calculated MW 52.5kDa
Additional Information
Gene ID 3856
Other Names Keratin, type II cytoskeletal 8, Cytokeratin-8, CK-8, Keratin-8, K8, Type-II keratin Kb8, KRT8, CYK8
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Cytokeratin 8 (KRT8) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT8
Synonyms CYK8
Function Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Cellular Location Cytoplasm. Nucleus, nucleoplasm Nucleus matrix
Tissue Location Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Research Areas
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Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular (�ring-like, perinuclear�) from ductal (�peripheral-predominant�) carcinoma of the breast.


Leube, R.E., et al. 1986. Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ. Differentiation 33: 69-85. |

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$ 324.00
Cat# AH11677
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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