Cytokeratin 10 (KRT10) (Suprabasal Epithelial Marker) Antibody
Mouse Monoclonal Antibody [Clone SPM261 ]
|Application ||IHC, IF, FC|
|Other Accession||3858, 99936|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Keratin, type I cytoskeletal 10, Cytokeratin-10, CK-10, Keratin-10, K10, KRT10, KPP|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Cytokeratin 10 (KRT10) (Suprabasal Epithelial Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Seen in all suprabasal cell layers including stratum corneum|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This MAb recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.
Barrott JJ et al. Proc Natl Acad Sci U S A 108:12752-7 (2011) | Reichelt J et al. J Cell Sci 110 ( Pt 18):2175-86 (1997
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.