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Cytokeratin 18 (KRT18) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone Cocktail ]

     
  • IHC -  Cytokeratin 18 (KRT18) Antibody - With BSA and Azide AH11720-20
    Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with Cytokeratin 18 Monoclonal Antibody (Cocktail).
    detail
  • IHC -  Cytokeratin 18 (KRT18) Antibody - With BSA and Azide AH11720-20
    Formalin-fixed, paraffin-embedded human Thyroid Carcinoma stained with Cytokeratin 18 Monoclonal Antibody (Cocktail).
    detail
  • IHC -  Cytokeratin 18 (KRT18) Antibody - With BSA and Azide AH11720-20
    Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Cytokeratin 18 Monoclonal Antibody (Cocktail).
    detail
  • IHC -  Cytokeratin 18 (KRT18) Antibody - With BSA and Azide AH11720-20
    Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with Cytokeratin 18 Monoclonal Antibody (Cocktail).
    detail
  • IHC -  Cytokeratin 18 (KRT18) Antibody - With BSA and Azide AH11720-20
    Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with Cytokeratin 18 Monoclonal Antibody (Cocktail).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, IF, FC
Primary Accession P05783
Other Accession 3875, 406013
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG's
Clone Names Cocktail
Calculated MW 45kDa
Additional Information
Gene ID 3875
Other Names Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18, CYK18
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Cytokeratin 18 (KRT18) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT18
Synonyms CYK18
Function Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Cellular Location Nucleus matrix {ECO:0000250|UniProtKB:Q5BJY9}. Cytoplasm, perinuclear region. Nucleus, nucleolus. Cytoplasm {ECO:0000250|UniProtKB:Q5BJY9}
Tissue Location Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Research Areas
Citations (0)
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Background

This MAb reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It is reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.

References

Lauerova, L., et al. 1988. Novel monoclonal antibodies defining epitope of human cytokeratin 18 molecule. Hybridoma 5: 495-504

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$ 219.00
$ 499.00
Cat# AH11720-20
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