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Laminin, gamma 1 (LAMC1) Antibody - With BSA and Azide
Rat Monoclonal Antibody [Clone A5 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, IF, FC |
|---|---|
| Primary Accession | P11047 |
| Other Accession | 3915, 609663, Q5VYE7, Q6NVY8 |
| Reactivity | Human, Mouse |
| Host | Rat |
| Clonality | Monoclonal |
| Isotype | Rat / IgG2a, kappa |
| Clone Names | A5 |
| Calculated MW | 210kDa |
| Gene ID | 3915 |
|---|---|
| Other Names | Laminin subunit gamma-1, Laminin B2 chain, Laminin-1 subunit gamma, Laminin-10 subunit gamma, Laminin-11 subunit gamma, Laminin-2 subunit gamma, Laminin-3 subunit gamma, Laminin-4 subunit gamma, Laminin-6 subunit gamma, Laminin-7 subunit gamma, Laminin-8 subunit gamma, Laminin-9 subunit gamma, S-laminin subunit gamma, S-LAM gamma, LAMC1, LAMB2 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Laminin, gamma 1 (LAMC1) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LAMC1 {ECO:0000303|PubMed:28397838, ECO:0000312|HGNC:HGNC:6492} |
|---|---|
| Function | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| Cellular Location | Secreted, extracellular space, extracellular matrix, basement membrane |
| Tissue Location | Found in the basement membranes (major component). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Laminins are large hetero-trimeric, non-collagenous glycoproteins composed of α, β, and γ chains. This MAb reacts with laminin B2/1 chain of ~210kDa and does not cross-react with other basement membrane components or fibronectin. Its specificity was established by immunoprecipitation and immunofluorescence of human skeletal muscle and kidney with laminin chain-specific MAbs. Epithelial sheets in vivo are separated from the mesenchymal elements of the stroma by a thin layer of a specialized type of extracellular matrix termed the basement membrane (BM). This structure consists of individual components, some of which are ubiquitous in BMs and some are not. The ubiquitous ones comprise laminin (LN), entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms. This MAb stains uniformly all human and murine basement membranes.
References
Ljubimov AV et. al., Int J Cancer, 1992; 50:562-566. | Ljubimov AV et. al. Lab Investigation, 1995; 72:461-473. | Folkvord et. al., J Histochem Cytochem, 1989; 37:105-113
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