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LH-beta (Luteinizing Hormone-beta) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone LHb/1214 ]

     
  • IHC -  LH-beta (Luteinizing Hormone-beta) Antibody - With BSA and Azide AH11748-20
    Formalin-fixed, paraffin-embedded human Pituitary stained with LH-beta Monoclonal Antibody (LHb/1214).
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, IF, FC
Primary Accession P01229
Other Accession 3972, 154704
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names LHb/1214
Calculated MW 22kDa
Additional Information
Gene ID 3972
Other Names Lutropin subunit beta, Lutropin beta chain, Luteinizing hormone subunit beta, LH-B, LSH-B, LSH-beta, LHB
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions LH-beta (Luteinizing Hormone-beta) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LHB
Function Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
Cellular Location Secreted.
Tissue Location Pituitary gland.
Research Areas
Citations (0)
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Background

Luteinizing hormone (LH) is a glycoprotein. Each monomeric unit is a sugar-like protein molecule; two of these make the full, functional protein. Its structure is similar to the other glycoproteins, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor; however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties.ĀLH is synthesized and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

References

Couzinet, B., et al. 1993. The control of gonadotrophin secretion by ovarian steroids. Hum. Reprod. 2: 97-101

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$ 219.00
$ 499.00
Cat# AH11748-20
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