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MAGE-1 (Target for Cancer Immunotherapy) Antibody

Mouse Monoclonal Antibody [Clone MA454 ]

  • IHC -  MAGE-1 (Target for Cancer Immunotherapy) Antibody AH11780
    Formalin-fixed, paraffin-embedded human Testis stained with MAGE-1 Monoclonal Antibody (MA454).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P43355
Other Accession 4100, 72879
Reactivity Human, Rat, Dog
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names MA454
Calculated MW 42-46kDa
Additional Information
Gene ID 4100
Other Names Melanoma-associated antigen 1, Antigen MZ2-E, Cancer/testis antigen 1.1, CT1.1, MAGE-1 antigen, MAGEA1, MAGE1, MAGE1A
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions MAGE-1 (Target for Cancer Immunotherapy) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MAGE1, MAGE1A
Function May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Cellular Location Cytoplasm. Nucleus.
Tissue Location Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas
Research Areas
Citations (0)

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Recognizes a protein of 42-46kDa, identified as MAGE-1. This MAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.


Qian, X et al. 2008. Mol Oncol. 2: 81-93

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$ 324.00
Cat# AH11780
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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