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>   home   >   Products   >   Primary Antibodies   >   Immunology   >    CD46 (Membrane Cofactor Protein) Antibody   

CD46 (Membrane Cofactor Protein) Antibody

Mouse Monoclonal Antibody [Clone 122.2]

     
  • FC -  CD46 (Membrane Cofactor Protein) Antibody AH11797-7
    FCM staining of human PBMC's using CD46 Monoclonal Antibody (122.2).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IF, FC
Primary Accession P15529
Other Accession 4179, 510402
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names 122.2
Calculated MW 56-66kDa
Additional Information
Gene ID 4179
Other Names Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46, CD46, MCP, MIC10
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD46 (Membrane Cofactor Protein) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD46
Synonyms MCP, MIC10
Function Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
Cellular Location Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single- pass type I membrane protein Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide
Tissue Location Expressed by all cells except erythrocytes.
Research Areas
Citations (0)

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Background

CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

References

Iwata, K., et al. 1995. Diversity of sites for measles virus binding and for inactivation of complement C3b and C4b on membrane cofactor protein CD46. J. Biol. Chem. 270: 15148-15152. | Liszewski, M.K., et al. 1996. Control of the complement system. Adv. Immunol. 61: 201-283. | Liszewski, M.K., et al. 1996. Membrane cofactor protein (MCP, CD46). Isoforms differ in protection against the classical pathway of complement. J. Immunol. 156: 4415-442

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$ 324.00
Cat# AH11797-7
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