MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) Antibody
Mouse Monoclonal Antibody [Clone 2F6 ]
|Application ||WB, IHC, IF, FC|
|Other Accession||4214, 653654|
|Isotype||Mouse / IgG2a, kappa|
|Calculated MW||195kDa (intact); 80kDa (cleaved)|
|Other Names||Mitogen-activated protein kinase kinase kinase 1, 184.108.40.206, MAPK/ERK kinase kinase 1, MEK kinase 1, MEKK 1, MAP3K1, MAPKKK1, MEKK, MEKK1|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MAPKKK1, MEKK, MEKK1|
|Function||Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.|
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Provided below are standard protocols that you may find useful for product applications.
Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli, including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4 and ASK 1 (MEK kinase- 5). MEK kinase-1 activates the ERK and c-Jun NH2-terminal kinase (JNK) pathways by phosphorylation of MAP2K1 and MAP2K4, and also activates the central protein kinases of the NFĪŗB pathway, CHUK and IKBKB. Additionally, MEK kinase-1 uses an E3 ligase through its PHD domain, a RING-finger-like structure, to target proteins for degradation through ubiquitination.
Guan, K.L. 1994. The mitogen activated protein kinase signal transduction pathway: from the cell surface to the nucleus. Cell. Signal. 6: 581-589
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